IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine
Abstract Ketamine, an N-methyl-D-aspartate receptor antagonist, exerts rapid and sustained antidepressant actions.Preclinical studies demonstrated that the release of brain-derived neurotrophic factor weathertech anchorage (BDNF) and vascular endothelial growth factor in the medial prefrontal cortex (mPFC) is essential for the antidepressant-like e