IGF-1 RELEASE IN THE MEDIAL PREFRONTAL CORTEX MEDIATES THE RAPID AND SUSTAINED ANTIDEPRESSANT-LIKE ACTIONS OF KETAMINE

IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine

Abstract Ketamine, an N-methyl-D-aspartate receptor antagonist, exerts rapid and sustained antidepressant actions.Preclinical studies demonstrated that the release of brain-derived neurotrophic factor weathertech anchorage (BDNF) and vascular endothelial growth factor in the medial prefrontal cortex (mPFC) is essential for the antidepressant-like e

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